Last edited by Jusida
Sunday, August 2, 2020 | History

2 edition of Regulation of pituitary gonadotrophin-releasing hormone receptors in vitro found in the catalog.

Regulation of pituitary gonadotrophin-releasing hormone receptors in vitro

Lawrence Sterling Young

Regulation of pituitary gonadotrophin-releasing hormone receptors in vitro

by Lawrence Sterling Young

  • 332 Want to read
  • 39 Currently reading

Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (Ph.D.) - University of Birmingham, Dept of Medicine, 1985.

Statementby Lawrence Sterling Young.
ID Numbers
Open LibraryOL14833069M

The use of gonadotrophin-releasing hormone analogues (GnRHa) has resulted in improved pregnancy rates in in-vitro fertilization (IVF) treatment cycles. Ciechanowska M, Łapot M, Malewski T, Mateusiak K, Misztal T, Przekop F. Effects of corticotropin-releasing hormone and its antagonist on the gene expression of gonadotrophin-releasing hormone (GnRH) and GnRH receptor in the hypothalamus and anterior pituitary gland of follicular phase ewes. Reprod., Fertil. Dev.

A single injection of gonadotrophin-releasing hormone (GnRH) (60 ng s.c., nmol) induced biphasic GnRH receptor regulation in normal intact adult female mice.   Regulation of Pituitary MT1 Melatonin Receptor Expression by Gonadotrophin-Releasing Hormone (GnRH) and Early Growth Response Factor-1 (Egr-1): In Vivo and In Vitro Studies Melatonin receptor expression exhibits profound developmental changes through poorly understood mechanisms.

Some associate apoplexy with administration of gonadotrophin-releasing hormone. Corticotropin-releasing It is carried via Hazum, E., , Receptor regulation by hormones: Relevance to secretion and other Luteinizing hormone; in vitro Profound Pituitary Suppression Following Oral Contraceptive Pretreatment in Gonadotropin. Shah BH, Milligan G. () The gonadotrophin-releasing hormone receptor of alpha T pituitary cells regulates cellular levels of both of the phosphoinositidase C-linked G proteins, Gq alpha and G11 alpha, equally. Mol. Pharmacol., 46 (1):


Share this book
You might also like
Preventing identity theft by terrorists and criminals

Preventing identity theft by terrorists and criminals

Extracts of several treatises wrote by the Prince of Conti

Extracts of several treatises wrote by the Prince of Conti

Screenshot

Screenshot

Directory of members research interests and BSG handbook

Directory of members research interests and BSG handbook

Nominations of Jane E. Newman and Rear Admiral John D. Bossler

Nominations of Jane E. Newman and Rear Admiral John D. Bossler

Classical symmetries

Classical symmetries

Programming for the learning disabled

Programming for the learning disabled

Say Goodbye to Sam

Say Goodbye to Sam

Bergman on Bergman

Bergman on Bergman

Report on conditions of employment in the iron and steel industry in the United States

Report on conditions of employment in the iron and steel industry in the United States

The road to Sleeping Dragon

The road to Sleeping Dragon

Country Garage

Country Garage

Regulation of pituitary gonadotrophin-releasing hormone receptors in vitro by Lawrence Sterling Young Download PDF EPUB FB2

The pattern of the gonadotropin-releasing hormone (GnRH) stimulus is critically important in the regulation of pituitary gonadotropin secretion and continuous infusions down-regulate secretion while intermittent pulses maintain luteinizing hormone (LH) and follicle-stimulating hormone (FSH) responsiveness.

We examined the effects of pulsatile GnRH administration on pituitary GnRH receptors (GnRH-R) and gonadotropin secretion Cited by:   The regulatory role of pituitary gonadotropinreleasing hormone (GnRH) receptors in the control of gonadotropin secretion was investigated in male and female rats after castration and sex steroid hormone replacement.

GnRH receptors were measured in homogenates of individual pituitaries by equilibration with I-labeled [D-Ser(tBu) 6]des-Gly 10 Cited by:   Cloning and sequencing of the sheep pituitary gonadotropin-releasing hormone receptor and changes in expression of its mRNA during the estrous cycle.

Mol. Cell. Endocrinol., RR Brooks, 1. and McNeilly, A.S., Regulation of gonadotrophin-releasing hormone receptor mRNA expression in the sheep.

Endocrinol., Cited by: 8. Insulin-like growth factor 1 (IGF1) is a key somatotropic hormone that may convey growth status to the reproductive endocrine system. This study examined effects of IGF1 alone or in combination with gonadotropin-releasing hormone (GnRH) on pituitary transcripts for GnRH receptor (GnRHR) variants, follicle-stimulating hormone (FSH), luteinizing hormone (LH), growth hormone (GH), and Cited by: The tonic and pulsatile release of pituitary gonadotropic hormones is regulated by LHRH (Fink, ).

In physiological circumstances, the secretion of LHRH is pulsatile rather than by: 3. In mammals, a current model suggests that pubertal reactivation of gonadotrophin-releasing hormone (GnRH) secretion down-regulates MT1 melatonin receptors in pituitary gonadotroph cells.

Abstract. Most peptide hormones exert their effects on target cells via interaction with specific receptors located on the cell membrane (for review see Amsterdam et al., a).

This interaction often results in changes in the concentration of the cellular receptors for the homologous hormone. Regulation of. gonadotropin hormone (GnRH), pituitary receptors for GnRH, and pituitary.

In an in vitro study with anterior pituitary cells, E2 did not stimulate LH release directly but. () Physiology of pituitary gonadotrophin-releasing hormone receptors. Ch 22 p In Recent Advances in Male Reproduction: Molecular Basis and Clinical Implication.

Ed D’Agata, Lipsett, Polosa & Van der Molen Raven Press New York. Gonadotropin-releasing hormone (GnRH) is a releasing hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior is a tropic peptide hormone synthesized and released from GnRH neurons within the peptide belongs to gonadotropin-releasing hormone constitutes the initial step in the hypothalamic.

R.N. Clayton, K. Channabasavaiah, J.M. Stewart and K.J. Catt. Hypothalamic regulation of pituitary gonadotrophin releasing hormone receptors: effects of hypothalamic lesions and a gonadotrophin releasing hormone antagonist. Endocrinol (). CrossRef Google Scholar.

The synthesis and secretion of LH and FSH are under regulation by stimulatory hypothalamic gonadotrophin-releasing hormone and negative feedback from gonadal sex steroid and peptide hormones, with further paracrine modulation by local factors produced within the pituitary gland itself.

Pituitary gonadotrophin-releasing hormone receptor up-regulation in vitro: dependence on calcium and microtubule function. Young LS, Naik SI, Clayton RN. Exogenous cyclic adenosine nucleotides increase gonadotrophin-releasing hormone (GnRH) receptors in intact cultured rat pituitary cells in a similar manner to that observed with GnRH itself.

In rat pituitary cells in vitro up-regulation of GnRH-R can be effected by several agents which stimulate LH release (GnRH, KCl, DbCAMP) as well as some which do not (Ca ionophore at low concentrations). Receptor up-regulation requires Ca2+ mobilisation and protein synthesis.

In mammals, a current model suggests that pubertal reactivation of gonadotrophin-releasing hormone (GnRH) secretion down-regulates MT1 melatonin receptors in pituitary gonadotroph cells, via the induction of early growth response factor-1 (EGR-1).

The GnRH receptor bindingassay was performed byincubation ofc.p.m. I-labelledGnRH-A (nmol/1)with approximately intact pituitary cells and non-specificbindingwas determined in the presence of an excess of unlabelled GnRH-A (pmol/1).

Total incubation volume was ml and the assay buffer was PBS containing01%BSA. The cells were incubated at °C for 80min and. Negative feedback regulation of hormone secretion exists at all levels of the hypothalamic–pituitary unit, but mostly by target gland hormones suppressing the pituitary and hypothalamus.

Local factors including cytokines, growth factors, nutrients, neuropeptides, and neurotransmitters, add further paracrine/autocrine complexity and can alter the delicate hormonal balance.

Melatonin receptor expression exhibits profound developmental changes through poorly understood mechanisms. In mammals, a current model suggests that pubertal reactivation of gonadotrophin-releasing hormone (GnRH) secretion down-regulates MT1 melatonin receptors in pituitary gonadotroph cells, via the induction of early growth response factor-1 (EGR-1).

The present work was designed to study certain aspects of the endocrine regulation of gonadotropin-releasing hormone receptor (GnRH-R) in the pituitary of the teleost fish tilapia. A GnRH-R was cloned from the pituitary of hybrid tilapia (taGnRH-R) and was identified as a typical seven-transmembrane receptor.

Abstract. The goldfish pituitary contains two classes of gonadotropin-releasing hormone (GnRH) binding sites, a high affinity/low capacity site and a low affinity/high capacity site (Habibiet al. a), whereas the catfish pituitary contains a single class of high affinity GnRH binding sites (De Leeuwet al.

Seasonal variations in pituitary GnRH receptor binding parameters, and the. A gonadotropin-releasing hormone agonist (GnRH agonist) is a type of medication which affects gonadotropins and sex hormones.

They are used for a variety of indications including in fertility medicine and to lower sex hormone levels in the treatment of hormone-sensitive cancers such as prostate cancer and breast cancer, certain gynecological disorders like heavy periods and endometriosis, high.

1. Introduction. Since the pioneer studies of Breton and colleagues showing that a hypothalamic factor stimulates the release of pituitary gonadotropic hormone in carp (Breton et al., ) and the characterization of the first fish GnRH, salmon GnRH (Sherwood et al., ), research on GnRH in teleost fish has focused increasing is not only due to the important potential.Gonadotrophin-releasing hormone (GnRH) agonists are widely used in reproductive medicine to implement down-regulation of pituitary gonadotrophin receptors.

The ensuing endogenous hypogonadotrophic state results in a marked decrease in cancellations of ovulation induction cycles for IVF and facilitates patient scheduling (Dor et al., a).